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Uit Nature
Host defense, viruses and apoptosis
Cell Death & Differentiation volume 8, pages113–126(2001)Cite this article
Once the virus has invaded the cell, however, a second host defense-mediated response is also triggered which involves the induction of a family of cytokines known as the interferons (IFNs). The IFNs, which are essential for initiating and coordinating a successful antiviral response, function by stimulating the adaptive arm of immunity involving cytotoxic T cells (CTLs), and by inducing a number of intracellular genes that directly prevent virus replication/cytolysis or that facilitate apoptosis. The IFN-induced gene family is now known to comprise the death ligand TRAIL, the dsRNA-dependent protein kinase (PKR), interferon regulatory factors (IRFs) and the promyelocytic leukemia gene (PML), all of which have been reported to be mediators of cell death.
Wiley Online Library
Wat kan de cel zoal doen tegen het virus?
1 Met interferon andere cellen waarschuwen
2 Virus RNA in stukken knippen
3 Virus enzymen in stukken knippen
4 Tegengaan dat het virus uit het endosoom komt
5 Tegengaan dat het virus zijn moleculen kan repliceren
6 Tegengaan dat het virus de cel verlaat
7 Apoptose ondergaan zodat het virus zich niet kan vermenigvuldigen